Explore the Molecular Universe

OmniPath integrates data from over 100 resources to provide a comprehensive view of molecular interactions, pathways, and biological annotations.

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Filter by interaction type, direction, and more

Reference Tracking

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Data Export

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Annotations Browser

Discover functional annotations, localizations, and biological properties

Functional Annotations

GO terms, pathways, and functions, and more

Localization Data

Cellular and subcellular locations

Intercellular Roles

Ligands, receptors, and signaling

Browse Annotations

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Database Statistics

Explore the sources and composition of our integrated databases

Last updated: 7/30/2025

Interactions

Molecular interactions between proteins

146

unique sources

2,882,750 records

Enzyme-Substrate

Enzyme-substrate relationships

unique sources

301,796 records

Complexes

Protein complex compositions

unique sources

46,200 records

Annotations

Functional annotations and properties

unique sources

9,848,863 records

Intercellular

Intercellular communication molecules

unique sources

332,447 records

Total

Across all databases

13,412,056

total records

Database Overview - Voronoi Treemap

Hierarchical visualization of all databases and their sources. Circle size represents the logarithm of record counts.

Databases

Interactions

Enzyme-Substrate

Complexes

Annotations

Intercellular

Interaction Types

Transcriptional

Post Translational

Mirna Transcriptional

Post Transcriptional

Small Molecule Protein

Top 10 Sources

Distribution of records across the top 10 data sources

All Sources

Complete list of all 146 sources

Source	Records	Percentage
DoRothEA	666,310	23.11%
PAZAR_DoRothEA	378,281	13.12%
ReMap_DoRothEA	275,556	9.56%
CollecTRI	129,234	4.48%
Wang	120,407	4.18%
ExTRI_CollecTRI	94,887	3.29%
SIGNOR	84,387	2.93%
HPRD	78,295	2.72%
SPIKE_LC	70,178	2.43%
ENCODE-proximal	56,144	1.95%
ENCODE-distal	41,548	1.44%
HTRIdb	39,679	1.38%
ProtMapper	31,266	1.08%
NTNU.Curated_CollecTRI	30,194	1.05%
ARACNe-GTEx_DoRothEA	26,592	0.92%
IntAct	26,379	0.92%
TRRUST_CollecTRI	25,495	0.88%
Lit-BM-17	24,590	0.85%
HOCOMOCO_DoRothEA	23,103	0.80%
PhosphoPoint	23,067	0.80%
GEREDB_CollecTRI	22,873	0.79%
JASPAR_DoRothEA	20,320	0.70%
SPIKE	19,148	0.66%
KEA	18,163	0.63%
KEGG	18,031	0.63%
TRRUST_DoRothEA	17,561	0.61%
MIMP	16,899	0.59%
RegNetwork_DoRothEA	16,732	0.58%
TRED_DoRothEA	16,732	0.58%
PhosphoSite_MIMP	16,046	0.56%
iPTMnet	14,179	0.49%
HuRI	13,596	0.47%
PhosphoSite_ProtMapper	13,350	0.46%
InnateDB	13,015	0.45%
phosphoELM_MIMP	12,738	0.44%
HPRD_MIMP	12,732	0.44%
Cui2007	11,977	0.42%
BioGRID	11,265	0.39%
Sparser_ProtMapper	10,600	0.37%
TFactS_CollecTRI	10,426	0.36%
SIGNOR_ProtMapper	10,094	0.35%
REACH_ProtMapper	9,898	0.34%
PhosphoSite	9,733	0.34%
NetworKIN_KEA	9,496	0.33%
NetPath	9,002	0.31%
CellTalkDB	8,688	0.30%
Cellinker	8,599	0.30%
LRdb	8,225	0.29%
miRTarBase	8,124	0.28%
ACSN	7,475	0.26%
PhosphoSite_KEA	7,091	0.25%
HTRI_CollecTRI	7,087	0.25%
DoRothEA-A_CollecTRI	6,799	0.24%
SIGNOR_CollecTRI	6,629	0.23%
PhosphoSite_noref	6,496	0.23%
iTALK	6,487	0.23%
Fantom5_LRdb	6,199	0.22%
talklr	6,074	0.21%
HTRIdb_DoRothEA	5,816	0.20%
DOMINO	5,657	0.20%
connectomeDB2020	5,656	0.20%
DIP	5,624	0.20%
KEGG-MEDICUS	5,386	0.19%
HPRD_KEA	5,071	0.18%
Ramilowski2015	4,789	0.17%
HPRD-phos	4,724	0.16%
PhosphoNetworks	4,658	0.16%
SignaLink3	4,641	0.16%
Adhesome	4,530	0.16%
RLIMS-P_ProtMapper	4,492	0.16%
EMBRACE	4,439	0.15%
CellPhoneDB	4,406	0.15%
Baccin2019	4,385	0.15%
CytReg_CollecTRI	4,255	0.15%
TFactS_DoRothEA	4,104	0.14%
phosphoELM_KEA	3,933	0.14%
TransmiR	3,868	0.13%
Ramilowski2015_Baccin2019	3,862	0.13%
Pavlidis2021_CollecTRI	3,778	0.13%
STRING_talklr	3,420	0.12%
HPRD_LRdb	3,401	0.12%
CellChatDB	3,369	0.12%
phosphoELM	3,235	0.11%
HPRD_talklr	3,228	0.11%
ncRDeathDB	2,902	0.10%
CA1	2,887	0.10%
KEGG_DoRothEA	2,851	0.10%
CancerCellMap	2,849	0.10%
Macrophage	2,823	0.10%
dbPTM	2,590	0.09%
Kinexus_KEA	2,490	0.09%
CellCall	2,476	0.09%
DEPOD	2,184	0.08%
HPMR_LRdb	2,176	0.08%
NCI-PID_ProtMapper	2,106	0.07%
CancerDrugsDB	2,101	0.07%
HPMR_talklr	2,096	0.07%
GOA_CollecTRI	2,070	0.07%
Reactome_LRdb	1,858	0.06%
ICELLNET	1,777	0.06%
ELM	1,755	0.06%
BEL-Large-Corpus_ProtMapper	1,645	0.06%
IntAct_DoRothEA	1,642	0.06%
HPMR_Cellinker	1,634	0.06%
Guide2Pharma	1,632	0.06%
CellChatDB-cofactors	1,528	0.05%
miRecords	1,525	0.05%
Reactome_ProtMapper	1,375	0.05%
HPMR	1,313	0.05%
TFe_DoRothEA	1,276	0.04%
ENCODE_tf-mirna	1,237	0.04%
scConnect	1,164	0.04%
DLRP_talklr	1,120	0.04%
ORegAnno_DoRothEA	1,093	0.04%
Guide2Pharma_Cellinker	1,080	0.04%
Li2012	1,023	0.04%
FANTOM4_DoRothEA	1,009	0.04%
Guide2Pharma_LRdb	925	0.03%
Guide2Pharma_talklr	882	0.03%
IntAct_CollecTRI	860	0.03%
MPPI	855	0.03%
Wojtowicz2020	821	0.03%
ORegAnno	780	0.03%
DLRP_Cellinker	772	0.03%
CellPhoneDB_Cellinker	678	0.02%
TCRcuration_SignaLink3	653	0.02%
DoRothEA-reviews_DoRothEA	640	0.02%
UniProt_LRdb	612	0.02%
TRRD_DoRothEA	552	0.02%
TRIP	459	0.02%
miR2Disease	435	0.02%
Kirouac2010	371	0.01%
miRDeathDB	331	0.01%
PDZBase	282	0.01%
MatrixDB	273	0.01%
NRF2ome	267	0.01%
ARN	248	0.01%
ABS	211	0.01%
AlzPathway	172	0.01%
DeathDomain	87	0.00%
InnateDB_SignaLink3	87	0.00%
ACSN_SignaLink3	79	0.00%
NFIRegulomeDB_DoRothEA	73	0.00%
Reactome_SignaLink3	69	0.00%
LncRNADisease	54	0.00%
cellsignal.com_LRdb	37	0.00%

About OmniPath

OmniPath is a database of molecular biology prior knowledge, combining data from over 150 resources to build 5 integrated databases:

Signaling network (interactions)
Enzyme-PTM relationships
Protein complexes
Protein annotations (function, localization, tissue, disease, structure)
Intercellular communication roles (ligand, receptor, intercell)

OmniPath Statistics

150+

Data Resources

Integrated Databases

1M+

Interactions

5M+

Annotations